Cannabis peptide interactions
Retatrutide {#retatrutide}
Most important interaction in Ben’s stack — goal conflict, not toxicity.
- THC stimulates appetite via hypothalamic CB1 → orexigenic
- Retatrutide suppresses appetite via GLP-1/GIP/glucagon → anorexigenic
- Human evidence: cannabis may reduce circulating GLP-1 levels
- Preclinical: reciprocal CB1/GLP-1R cross-talk (cAMP, insulin signaling)
- Net effect: cannabis likely partially blunts Retatrutide appetite suppression and weight-loss signaling
- No dangerous PK interaction identified — this is a signal-conflict issue
BPC-157
No documented direct interaction. Weak theoretical overlap via DA/5-HT/NO systems only. Not a practical concern.
TB-500
No documented interaction. No known endocannabinoid system overlap. Not a practical concern.
GHK-Cu
No documented interaction. No known direct endocannabinoid overlap. Not a practical concern.