GLP-1 vs CB1 cross-talk
What it is
GLP-1 and CB1 signaling influence appetite and metabolic regulation in opposing directions.
Why it matters for Vitals
This note explains why cannabis may work against Retatrutide’s appetite-suppression and weight-loss goals.
Main evidence
- THC stimulates appetite via hypothalamic CB1 signaling
- GLP-1 agonism suppresses appetite and promotes satiety
- preclinical work suggests reciprocal interaction between CB1 and GLP-1R signaling, including effects on cAMP and insulin secretion
- human evidence suggests cannabis may reduce circulating GLP-1 levels
Practical implication
This looks less like a dangerous drug interaction and more like a signal conflict: cannabis may partially blunt GLP-1 appetite suppression.