Cardiovascular risk
Quantified risk
| Outcome | Relative risk |
|---|---|
| Acute coronary syndrome | 1.29 |
| Stroke | 1.20 |
| Cardiovascular death | 2.10 |
| Daily use — MI | 1.49 (some datasets) |
| Daily use — stroke | 2.16 (some datasets) |
Signal appears strongest with smoked cannabis (particle inhalation, rapid catecholamine release).
Mechanism
- Acute: sympathetic activation → HR rise, BP increase
- THC-induced platelet activation possible
- Smoking adds particulate matter cardiovascular burden
Vitals interpretation
Not cardiovascularly neutral. Risk is modest in absolute terms for healthy occasional users but non-trivial for deconditioned users, those with existing CVD, or daily smokers.
Related
Cannabis, HRV signatures, Cannabis detection model, Asundexian